
"Yes I'm a girl, you idiot!!" - Royal Pain
Gwendoline "Gwen" Grayson, born as Susan "Sue" Tenny and also known as Royal Pain, is the main antagonist of Sky High.
She is portrayed by Mary Elizabeth Winstead, and voiced by Patrick Warburton for the armor vocal effect.
Backstory[]

Gwen Grayson
Gwen Grayson was originally known as Sue Tenny, a brilliant student at Sky High while The Commander and Jetstream (Will Stornghold's parents) were also attending the school. While there, she invented the Pacifier, a weapon used to transform people into babies. Despite her prodigious abilities, she was underestimated and classified a sidekick.
Outraged and jealous by this result, she hatched a plan to destroy Sky High and replace it with her own school for super villains by transforming everyone there into babies and raise them into such. This plan failed after The Commander and Jetstream fought against her, but the pacifier unintentionally exploded in the process. After this, she was thought to have died, but was actually transformed into a baby and taken in by Stitches and adopted the name Gwen Grayson. She'd been plotting her revenge ever since.
She later meets Will after (once again) entering her teen years and started dating him, with the former unaware the Gwen is the villainous Royal Pain. During the School Dance, she reveals herself as Royal Pain and turns the students, teachers, and staff into babies.
She is defeated by Will after a fierce battle. She is now in solitary confinement.