Sir John Dee is the Bigger Bad of Toei's 2017 game, Nioh.
Sir John Dee is the mastermind of the Amrita project, aiming to raise England to dominate the world with himself as its true puppet-ruler from the shadows. He creates Edward Kelley as a sentient, disposable weapon, and sends him to Japan with the intent of annihilating everything he can and killing countless people to harvest Amrita with the knowledge he can just create a new Kelley if the need arises. Torturing to death on a large scale those involved in the first stage of the Amrita project, he also has others abducted to brutally experiment on them in order to create new demons in order to harvest more Amrita.