Dr. Samuel Isaacs is the main villain in Resident Evil: Extinction. He is an Umbrella Corporation scientist, in charge of the Nemesis Program and later the Umbrella Science Division. Isaacs forced Perry to leave Danville for good after he threatens him to harm Phineas.
The B Team Storyline[]
LOTM: Next Generation Island Tour[]
After the events of Extinction, he join forces with BlackGarurumon to infect the Multi-Universe with T-Virus. He also infects Applejack, and Fluttershy with T-Virus.
Issacs arrives with his allies to get the four members sent out of trouble with Sinister's allies. Issacs talk to Shaw and Birkin about what Frollo and Braniac gave him. This is regarding mutants and he deducts correctly that it's The black haired girl with the bow,as Predaking mentioned he noticed it when he was searching for Bender which goes into Shaw's vision of his world. He and Paul McDaggett decide to get more for Soran for his plan on the dogs. With their help, he manages to get his experiment on. Paul and Issacs annouce that their pound puppies died due to Jesse and that they must use another subject. Issacs and Birkin have managed to do their work and infect some party with the T Virus. Issacs notices the heroes aren't coming quiet so he decides on execution, once they escape he has enough which means well he has a plan. He ends up mutating himself as he has enough of the heroes, Mister Sinister, and Jesse.
Issacs saves McDaggett from Jesse and Russell though they aren't done yet and make it their word to take them down if they don't stop the Jack White Act. The Children of BlackGarurumon members led by Cronus make an ambush on the heroes such like Anarky knew would happen. Issacs is poisoned by Bender and Discord and as a result alongside Le Fou, Evil Buzz, Motherfucker, Lady Tremaine, Luther, Morgana ,Gaston and all of BlackGarurumon's armies and they all are killed.
Allies and Enemies[]
Allies: BlackGarurumon, Cronus, Sunset Shimmer, White Wolf, Evanora, Theodora, William Birkin, Sebastian Shaw, Lady Tremaine, Morgana le Fay, Predaking, Ultraman, Evil Buzz Lightyear, Paul McDaggett, Red Mist, Tolian Soran, Luther, Niju, Brainiac, Lord of Darkness, SkekUng, BlackMetalGreymon, Baron Zemo, Ares(DC), Mandrake, Judge Claude Frollo, Gaston, Mor'du, Unalaq, Katz, Mooch
Enemies: Alice, Jake Muller, Jill Valentine, Timothy Cain, the B Team, the Alpha Team, Slade's ensemble, the Multi-Universal Resistance, Sinisters of Evil
Gallery[]
