Misanthropes

You see... humans... are a unique type of pest. Multiplying... and poisoning our world, all while enforcing a structure of their own. A deeply... unnatural structure. Where others saw order, I saw a straitjacket. A cruel, oppressive world dictated by made-up rules. Seconds, minutes, hours, days, weeks, months, years, decades! Each life, a faded, lesser copy of the one before! WAKE UP, EAT, WORK, SLEEP, REPRODUCE AND DIE! Everyone... is just... waiting. Waiting... for it all... to be... over. All while performing in a silly, terrible play, day after day. I could not do that. I could not close off my mind and join in the madness, I could not... pretend. Then I realized... I didn't have to. - Vecna/Henry Creel's view on humanity

Villains that have a serious hatred for humanity or the nearest equivalent in their respective setting, and may even be genocidal in that regard. Misanthropy can lead villains to committing terrible crimes as they no longer have compassion towards their fellow man (in fact, such villains often despise their fellow man).

Many human villains themselves (such as primate humans, cavemen, or modern-day humans) may also be misanthropic or self-hating humans, as they view their species as mentally stupid, inferior, irredeemably flawed, or worthless. This could also include undead humans (ghosts, zombies, vampires, etc.) that are disdainful for the living.

Many non-human villains (such as aliens, robots, animals, plants, humanoids, monsters, etc) may also be misanthropic, as they view humans as mentally stupid, inferior, irredeemably flawed, worthless, or even oppressive. However, it should be noted that not all non-human villains are necessarily misanthropic.

Good examples of misanthropes are Ultron, Godzilla, The Joker, Shere Khan, Megatron, and Cthulhu.