Characters who have Brother-Sister Relationship

This is for Males and Females who are close friends with each other. So close they are like Brothers and Sisters,they could have been a couple before this or could gone beyond this

Examples:

Dib with Bubbles, Bender, Milo, Lizbeth, Edd , Boomer and Nina (Despite himself being involved with Bubbles)

Bender, Heloise and Skipper and that extended to Twilight Sparkle, Marceline, Phineas, Isabella, Suede, Slade, Anti Cosmo, Jack Bauer, Gohan, Connor and Makoto(Though Phineas and Isabella are involved romantically),

Lizbeth's inital realtionship with Boomer, before becoming a couple and most of her realtionships with her closest friends

Slade with Anti Cosmo

Knuckles Riso best friends and is protected by Death the Kid, Jinx, Rainbow Dash, and Sonic the Hedgehog.

Maka Albarn and Crona

Lara Croft has been friends with Chappie, since Lara lost her father and Chappie lost his mother.