Dr. Sam Isaacs

Dr. Samuel Isaacs is the main villain in Resident Evil: Extinction. He is an Umbrella Corporation scientist, in charge of the Nemesis Program and later the Umbrella Science Division. He is also the responsible of Derek's parents death.

He is also the main reponsible for Turbo Mecha Sonic's creation.

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Allies: BlackGarurumon, Cronus, Keyser Soze, Sunset Shimmer, White Wolf, Evanora, Theodora, William Birkin, Sebastian Shaw, Lady Tremaine, Morgana le Fay, Predaking, Evil Buzz Lightyear, Paul McDaggett, The Lich, Red Mist, Tolian Soran, Luther, Niju, Brainiac, Dark Star, Lord of Darkness, SkekUng, SkekSis, Cameron, Baron Zemo, Ares(DC), Cyrus Kriticos, Mandrake, Judge Claude Frollo, Gaston, Mor'du, Katz

Enemies: Alice, Jake Muller, Jill Valentine, Derek, The B Team, The Alpha Team, The Multiversal Resistence, Sinisters of Evil

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