Dr. Nefario

Joseph Albert Nefario, most commonly referred to as Dr. Nefario, is the tetartagonist of Despicable Me and the (former) quarernary antagonist of Despicable Me 2. He is Gru's gadgeteer residing in his underground lair and laboratories. He builds and designs most of Gru's machines. Gru and Dr. Nefario seem to have been trying to shock the world with "The True Crime of the Century" for several years.

Although, Nefario has doubts about Gru's plans due to lack of funds, and his new found love for his adopted daughters, he still considers him to be "one of the greats" in the supervillain world. Dr. Nefario also has terrible hearing, mistaking Gru's orders for "dart gun" and "cookie robots" as "fart gun" and "boogie robots", respectively. He is one of the tritagonists in Despicable Me and a former supporting antagonist in Despicable Me 2. He makes silent cameos in both Minions and Despicable Me 3.