Madame Gao

Madame Gao is a very powerful woman running her own trade of heroin in Hell's Kitchen with the aid of Rand Enterprises. While fighting off the efforts of the new vigilante Daredevil, Gao betrayed Wilson Fisk and, as a result, decided to leave New York City to reflect upon the future. However she soon returned and gained a rival with the Blacksmith who was selling his own heroin, so Gao manipulated Daredevil and Punisher to kill him. Gao's heroin trade was interrupted again by the return of Danny Rand, who used both his position within Rand Enterprises as well as his Iron Fist title to destroy Gao's trade. This led to Gao being captured by a rival Handleader named Bakuto until Gao was able to manipulate Rand and set herself free to exact her own revenge.